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A Functional-Group-Tolerant Catalytic trans Hydrogenation of Alkynes

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  • Generous financial support by the Max-Planck-Gesellschaft, the Fonds der Chemischen Industrie, and the Alexander von Humboldt-Stiftung (fellowship to B.S.) is gratefully acknowledged. We thank the analytical departments of our Institute for excellent assistance.

Abstract

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Against the rules: During the hundred years following Sabatier's groundbreaking work on catalytic hydrogenation, syn delivery of the H atoms to the π system of a substrate remained the governing stereochemical rule. An exception has now be found with the use of cationic [Cp*Ru] templates, which accounts for the first practical, functional-group-tolerant, broadly applicable and highly E-selective semihydrogenation method for alkynes (see scheme).

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