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Keywords:

  • antitumor agents;
  • cis-platin;
  • ligand design;
  • nanoformulation;
  • titanium
Thumbnail image of graphical abstract

A nanoformulated trinuclear hydrolysis product of a bis(alkoxo) salan–TiIV complex shows high antitumor activity (see picture), which identifies it as an active species in cells. Additional highly stable mononuclear derivatives also show high activity, when formulated into nanoparticles, thus evincing that biologically friendly TiIV can provide high cytotoxicity with controlled biological function.