High Antitumor Activity of Highly Resistant Salan–Titanium(IV) Complexes in Nanoparticles: An Identified Active Species


  • We thank Dr. Shmuel Cohen for crystallography work. Funding was received from the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement (No.239603), and partially from the Israel Science Foundation (grant No.124/09) and Lower Saxony Ministry of Science.


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A nanoformulated trinuclear hydrolysis product of a bis(alkoxo) salan–TiIV complex shows high antitumor activity (see picture), which identifies it as an active species in cells. Additional highly stable mononuclear derivatives also show high activity, when formulated into nanoparticles, thus evincing that biologically friendly TiIV can provide high cytotoxicity with controlled biological function.