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Direct Pd-Catalyzed Cross-Coupling of Functionalized Organoaluminum Reagents


  • We thank the Fonds der Chemischen Industrie and the European Research Council (ERC) for financial support. We also thank BASF AG (Ludwigshafen), W. C. Heraeus GmbH (Hanau), and Chemetall GmbH (Frankfurt) for the generous gift of chemicals.


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A handsome couple: Through the use of the simple Pd catalyst [Pd(tmpp)2Cl2] (tmpp=tris(2,4,6-trimethoxyphenyl)phosphine) and THF/DMF as solvent, various aryl-, heteroaryl-, benzyl- and alkylaluminum reagents can be readily cross-coupled with aryl or heteroaryl iodides, bromides, and nonaflates, and in special cases even with chlorides and triflates. This cross-coupling tolerates free NH2 groups, aldehydes, ketones, esters, and nitro functions.

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