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Keywords:

  • bodipy;
  • DNA catalyst;
  • DNA sensing;
  • fluorogenic reaction;
  • signal amplification
Thumbnail image of graphical abstract

Phosphine ligands were covalently tethered to short oligonucleotide strands such that active palladium complexes formed in the presence of a specific nucleic acid target. This catalytic center on the double-stranded DNA then converted water-soluble iodo-BODIPY dyes, present in excess, into highly emissive deiodinated reporters (see picture). This approach is suitable for the rapid colorimetric or fluorimetric detection of nucleic acid targets with a lower detection limit of just 10 pM.