Acyclic Cucurbit[n]uril-Type Molecular Containers Bind Neuromuscular Blocking Agents In Vitro and Reverse Neuromuscular Block In Vivo

Authors

  • Dr. Da Ma,

    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
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  • Ben Zhang,

    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
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  • Dr. Ulrike Hoffmann,

    1. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts (USA)
    2. Klinik für Anaesthesiologie, Klinikum rechts der Isar, TU München, Ismaningerstr. 22, 81675 München (Germany)
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  • Dr. Martina Grosse Sundrup,

    1. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts (USA)
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  • Prof. Dr. Matthias Eikermann,

    Corresponding author
    1. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts (USA)
    2. Department of Anesthesia and Intensive Care Medicine, Essen-Duisburg University, (Germany)
    • Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts (USA)
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  • Prof. Lyle Isaacs

    Corresponding author
    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
    • Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
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  • We thank the National Science Foundation (CHE-0615049 and CHE-1110911 to L.I.) for financial support. M.E. thanks the Department of Anesthesia, Critical Care, and Pain Medicine at the Massachusetts General Hospital in Boston for financial support.

Abstract

original image

Be My Guest: Two acyclic cucurbit[n]uril-type receptors that carry SO3-groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.

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