Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies


  • This work was funded by the Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency, for Science, Technology and Research, Singapore), IBM Almaden Research Center (USA), University of California, Los Angeles (UCLA (USA)), Zhejiang University (China).


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Fighting the resistance: Biodegradable and injectable/moldable hydrogels with hierarchical nanostructures (see picture) were made with broad-spectrum antimicrobial activities and biofilm-disruption capability. They demonstrate no cytotoxicity in vitro, and show excellent skin biocompatibility in animals. These hydrogels have great potential for clinical use in prevention and treatment of various multidrug-resistant infections.