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Keywords:

  • fluorescence;
  • in vivo imaging;
  • quantum dots;
  • second near-infrared window;
  • tumor imaging
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Hits the dot: Ag2S quantum dots (QDs) with bright near-infrared-II fluorescence emission (around 1200 nm) and six-arm branched PEG surface coating (see scheme) were synthesized for in vivo small-animal imaging. The 6PEG-Ag2S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half-life of approximately 4 h. Clearance of the injected 6PEG-Ag2S QDs occurs mainly through the biliary pathway in mice.