These authors contributed equally to this work.
In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region†
Article first published online: 5 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 39, pages 9818–9821, September 24, 2012
How to Cite
Hong, G., Robinson, J. T., Zhang, Y., Diao, S., Antaris, A. L., Wang, Q. and Dai, H. (2012), In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region . Angew. Chem. Int. Ed., 51: 9818–9821. doi: 10.1002/anie.201206059
This work is supported by NIH-NCI 5R01CA135109-02 to H. Dai, the Chinese Academy of Science “Bairen Ji Hua” program, the Chinese Academy of Science “Strategic Priority Research Program” (XDA01030200), the Chinese Ministry of Science and Technology (2011CB965004) and the National Science Foundation of China (20173225) to Q. Wang, and a Stanford Graduate Fellowship to G. Hong.
- Issue published online: 19 SEP 2012
- Article first published online: 5 SEP 2012
- Manuscript Received: 29 JUL 2012
- NIH-NCI. Grant Number: 5R01CA135109-02
- Chinese Academy of Science. Grant Number: XDA01030200
- Chinese Ministry of Science and Technology. Grant Number: 2011CB965004
- National Science Foundation of China. Grant Number: 20173225
- in vivo imaging;
- quantum dots;
- second near-infrared window;
- tumor imaging
Hits the dot: Ag2S quantum dots (QDs) with bright near-infrared-II fluorescence emission (around 1200 nm) and six-arm branched PEG surface coating (see scheme) were synthesized for in vivo small-animal imaging. The 6PEG-Ag2S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half-life of approximately 4 h. Clearance of the injected 6PEG-Ag2S QDs occurs mainly through the biliary pathway in mice.