Communication

At Last: Erythropoietin as a Single Glycoform†

  1. Dr. Ping Wang1,‡,
  2. Dr. Suwei Dong1,‡,
  3. Dr. John A. Brailsford1,
  4. Dr. Karthik Iyer1,
  5. Dr. Steven D. Townsend1,
  6. Dr. Qiang Zhang1,
  7. Dr. Ronald C. Hendrickson3,
  8. Dr. JaeHung Shieh2,
  9. Dr. Malcolm A. S. Moore2,
  10. Prof. Samuel J. Danishefsky1,4,*

Article first published online: 25 SEP 2012

DOI: 10.1002/anie.201206090

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 46, pages 11576–11584, November 12, 2012

Additional Information

How to Cite

Wang, P., Dong, S., Brailsford, J. A., Iyer, K., Townsend, S. D., Zhang, Q., Hendrickson, R. C., Shieh, J., Moore, M. A. S. and Danishefsky, S. J. (2012), At Last: Erythropoietin as a Single Glycoform . Angew. Chem. Int. Ed., 51: 11576–11584. doi: 10.1002/anie.201206090

Author Information

  1. 1

    Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065 (USA)

  2. 2

    Cell Biology Program, Sloan-Kettering Institute for Cancer Research (USA)

  3. 3

    Department of Pharmacology and Chemistry, Sloan-Kettering Institute for Cancer Research (USA)

  4. 4

    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027 (USA)

  1. ‡

    These authors contributed equally to this work.

*Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065 (USA)

  1. †

    This research was supported by NIH grants CA28824 and HL025848 (S.J.D.). S.D.T. is grateful to Weill Cornell Medical School for an NIH postdoctoral fellowship.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 7 NOV 2012
  2. Article first published online: 25 SEP 2012
  3. Manuscript Received: 30 JUL 2012

Funded by

  • NIH. Grant Numbers: CA28824, HL025848

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Keywords:

  • aspartylation;
  • erythropoietin;
  • glycoproteins;
  • total synthesis
Thumbnail image of graphical abstract

Wild thing: The first total synthesis of wild-type erythropoietin glycoprotein (see picture) has been accomplished. The erythropoietic activity of the synthetic folded protein has been demonstrated.

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