These authors contributed equally to this work.
Observation of Multiphoton-Induced Fluorescence from Graphene Oxide Nanoparticles and Applications in In Vivo Functional Bioimaging†
Article first published online: 24 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 42, pages 10570–10575, October 15, 2012
How to Cite
Qian, J., Wang, D., Cai, F.-H., Xi, W., Peng, L., Zhu, Z.-F., He, H., Hu, M.-L. and He, S. (2012), Observation of Multiphoton-Induced Fluorescence from Graphene Oxide Nanoparticles and Applications in In Vivo Functional Bioimaging . Angew. Chem. Int. Ed., 51: 10570–10575. doi: 10.1002/anie.201206107
This work was partially supported by the Science and Technology Department of Zhejiang Province, the National Basic Research Program (973) of China (2011CB503700), the Special Financial Grant from the China Postdoctoral Science Foundation (No. 201104741), the National Natural Science Foundation of China (61275190, 61008052, 61178062, and 60990322), and the Fundamental Research Funds for the Central Universities. J.Q. is grateful to Dr. S. S. Liu for help with two-photon laser scanning confocal microscopy. We also express our deepest gratitude towards Prof. Z. P. Xu’s group for their help in the cell proliferation assay.
- Issue published online: 10 OCT 2012
- Article first published online: 24 SEP 2012
- Manuscript Received: 30 JUL 2012
- Science and Technology Department of Zhejiang Province
- National Basic Research Program (973) of China. Grant Number: 2011CB503700
- China Postdoctoral Science Foundation. Grant Number: 201104741
- National Natural Science Foundation of China. Grant Numbers: 61275190, 61008052, 61178062, 60990322
- Fundamental Research Funds for the Central Universities
- graphene oxide;
- multiphoton induced luminescence;
- subcellular imaging
Lightening organelles: A femtosecond laser can excite multiphoton-induced luminescence of graphene oxide nanoparticles. The flow, distributions, and clearance of intravenously injected GO-PEG nanoparticles in the blood vessel of mice could be observed clearly by two-photon imaging. The 3D distribution of microinjected GO-PEG nanoparticles in a mice brain could also be reconstructed with two-photon microscopy.