We thank Chengdu Institute of Biological Products for sharing the vaccine products. This work is supported by the Fundamental Research Funds for the Central Universities and National 973 Project of China (2012CB518904).
Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration†
Article first published online: 24 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 42, pages 10576–10579, October 15, 2012
How to Cite
Wang, G., Li, X., Mo, L., Song, Z., Chen, W., Deng, Y., Zhao, H., Qin, E., Qin, C. and Tang, R. (2012), Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration . Angew. Chem. Int. Ed., 51: 10576–10579. doi: 10.1002/anie.201206154
- Issue published online: 10 OCT 2012
- Article first published online: 24 SEP 2012
- Manuscript Received: 1 AUG 2012
- Fundamental Research Funds for the Central Universities and National 973 Project of China. Grant Number: 2012CB518904
We're not gonna bake it: In situ biomineralization creates an egg-like shell on vaccine particles to improve their thermostability. Different from the bare vaccine (squares), the biomineralized vaccine (red circles) can be stored at ambient temperature without refrigeration for up to a week and retain biological activity both in vitro (see graph), as well as in a mouse model.