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Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration


  • We thank Chengdu Institute of Biological Products for sharing the vaccine products. This work is supported by the Fundamental Research Funds for the Central Universities and National 973 Project of China (2012CB518904).


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We're not gonna bake it: In situ biomineralization creates an egg-like shell on vaccine particles to improve their thermostability. Different from the bare vaccine (squares), the biomineralized vaccine (red circles) can be stored at ambient temperature without refrigeration for up to a week and retain biological activity both in vitro (see graph), as well as in a mouse model.