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Synthesis of Five- and Six-Membered Benzocyclic Ketones through Intramolecular Alkene Hydroacylation Catalyzed by Nickel(0)/N-Heterocyclic Carbenes


  • This work was supported by a Grant-in-Aid for Scientific Research (No. 21245028) and for Scientific Research on Innovative Area “Molecular Activation Directed toward Straightforward Synthesis” (No. 23105546) from MEXT, and the Asahi Glass Foundation. Y.H. expresses his special thanks for the research fellowships for young scientists from the Japan Society for the Promotion of Science (JSPS).


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Getting some closure: Mechanistic studies supported the participation of an oxanickelacycle complex in the hydroacylation step of the title reaction, which proceeds without decarbonylation even in the absence of well-known chelation assistance by heteroatoms.

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