This work is supported by the EPFL and the European Research Council under the European Community’s Seventh Framework Program (FP7 2007–2013)/ERC Grant agreement no 257891. We thank Dr. R. Scopelliti for X-ray crystallographic analysis.
Access to Sultams by Rhodium(III)-Catalyzed Directed CH Activation†
Article first published online: 23 SEP 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 42, pages 10610–10614, October 15, 2012
How to Cite
Pham, M. V., Ye, B. and Cramer, N. (2012), Access to Sultams by Rhodium(III)-Catalyzed Directed CH Activation . Angew. Chem. Int. Ed., 51: 10610–10614. doi: 10.1002/anie.201206191
- Issue published online: 10 OCT 2012
- Article first published online: 23 SEP 2012
- Manuscript Received: 2 AUG 2012
- European Research Council. Grant Number: 257891
- CH activation;
- homogenous catalysis;
Director's cut: The pharmaceutically relevant sulfonamide group is shown to be a competent directing group for [Cp*Rh(OAc)2]-catalyzed CH functionalizations. Reactions of the cyclometalated intermediate with internal alkynes provide access to a wide range of sultam derivatives. The reaction is high yielding and works best under aerobic conditions with catalytic amounts of CuOAc as an oxidation mediator. Cp*=C5Me5.