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Keywords:

  • C[BOND]H activation;
  • heterocycles;
  • homogenous catalysis;
  • rhodium;
  • sulfonamides
Thumbnail image of graphical abstract

Director's cut: The pharmaceutically relevant sulfonamide group is shown to be a competent directing group for [Cp*Rh(OAc)2]-catalyzed C[BOND]H functionalizations. Reactions of the cyclometalated intermediate with internal alkynes provide access to a wide range of sultam derivatives. The reaction is high yielding and works best under aerobic conditions with catalytic amounts of CuOAc as an oxidation mediator. Cp*=C5Me5.