Communication

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α†

  1. Dennis L. Buckley1,
  2. Dr. Jeffrey L. Gustafson1,
  3. Dr. Inge Van Molle2,
  4. Dr. Anke G. Roth1,
  5. Dr. Hyun Seop Tae1,
  6. Dr. Peter C. Gareiss1,
  7. Prof. William L. Jorgensen1,
  8. Dr. Alessio Ciulli2,
  9. Prof. Craig M. Crews1,*

Article first published online: 12 OCT 2012

DOI: 10.1002/anie.201206231

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 46, pages 11463–11467, November 12, 2012

Additional Information

How to Cite

Buckley, D. L., Gustafson, J. L., Van Molle, I., Roth, A. G., Tae, H. S., Gareiss, P. C., Jorgensen, W. L., Ciulli, A. and Crews, C. M. (2012), Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α . Angew. Chem. Int. Ed., 51: 11463–11467. doi: 10.1002/anie.201206231

Author Information

  1. 1

    Departments of Chemistry, Molecular, Cellular & Developmental Biology and Pharmacology and Center for Molecular Discovery, Yale University, New Haven, CT 06511 (USA)

  2. 2

    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK)

*Departments of Chemistry, Molecular, Cellular & Developmental Biology and Pharmacology and Center for Molecular Discovery, Yale University, New Haven, CT 06511 (USA)

  1. †

    This research was supported in part by the NIH (AI084140, GM032136), BBSRC (BB/G023123/1), and EC (PIEF-GA-2010-275683). J.L.G. thanks the NIH for a postdoctoral fellowship (F32GM10052101). A.G.R. is a Leopoldina-Nationale Akademie der Wissenschaften Postdoctoral Fellow. We are grateful to the beamline scientists of the Proxima-1 beamline at the Soleil synchrotron facility for their assistance.

Publication History

  1. Issue published online: 7 NOV 2012
  2. Article first published online: 12 OCT 2012
  3. Manuscript Received: 3 AUG 2012

Funded by

  • NIH. Grant Numbers: AI084140, GM032136
  • BBSRC. Grant Number: BB/G023123/1
  • EC. Grant Number: PIEF-GA-2010-275683

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (740K)

Options for accessing this content:

  • If you have access to this content through a society membership, please first log in to your society website.
  • If you would like institutional access to this content, please recommend the title to your librarian.
  • Login via other institutional login options http://onlinelibrary.wiley.com/login-options.
  • You can purchase online access to this Article for a 24-hour period (price varies by title)
    • If you already have a Wiley Online Library or Wiley InterScience user account: login above and proceed to purchase the article.
    • New Users: Please register, then proceed to purchase the article.

If your institution is a registered Wiley Online Library customer, you can log in under your institution's name to see our content. This access is provided by Shibboleth or Athens.

Type your institution's name in the box below. If your institution is a Wiley customer, it will appear in the list of suggested institutions.

Please register to:

  • Save publications, articles and searches
  • Get email alerts
  • Get all the benefits mentioned below!

Register now >

Get PDF (740K)