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Synthesis of Aromatic α-Aminoesters: Palladium-Catalyzed Long-Range Arylation of Primary Cmath image[BOND]H Bonds

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  1. Errata: Corrigendum: Synthesis of Aromatic α-Aminoesters: Palladium-Catalyzed Long-Range Arylation of Primary Cmath image[BOND]H Bonds Volume 52, Issue 5, 1354, Article first published online: 23 January 2013

  • This work was supported financially by the Agence Nationale de la Recherche (programme blanc “EnolFun”), the Ministère de l’Enseignement Supérieur et de la Recherche, Région Rhône-Alpes (programme CIBLE), the Université Claude Bernard Lyon 1, and the Institut Universitaire de France. We also thank A. Ledoux for preliminary synthetic work, and Dr. E. Jeanneau (UCBL) and Dr. C. Duhayon (LCC Toulouse) for crystallographic data collection, structure solution, and refinement.

Abstract

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Remote control: The title reaction for β–ζ arylation of α-amino esters with aryl bromides is described. This reaction, which occurs selectively at the terminal position of linear alkyl chains, gives rise to synthetically useful (hetero)arylalanines and homologues after debenzylation (see scheme).

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