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Ruthenium-Catalyzed ortho-Alkylation of Phenols with Alcohols by Dehydrative Coupling


  • We gratefully acknowledge funding from the EPSRC and the University of Bath.


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Only water: Phenols have been shown to undergo a ruthenium-catalyzed ortho-alkylation reaction (see scheme; Cy=cyclohexyl). Unactivated alcohols are used as the alkylating agents and water is the only by-product that is generated, making this transformation more atom-economical and greener than traditional methods.

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