Temperature-Switched Binding of a RuII(dppz)/DNA Light-Switch Complex


  • We are grateful to the EPSRC and the BBSRC for studentships (M.W. and V.G.) and the Royal Society Newton Fellowship Scheme (E.C.). dppz=Dipyridylphenazine.


original image

Cool to switch on: Although a Ru(dppz)-based complex binds to the grooves of duplex DNA at room temperature and above, it intercalates into duplex DNA at 10 °C, thus displaying a light-switch effect (see picture, dppz=dipyridylphenazine). Furthermore, once intercalated at low temperatures, emission does not disappear, even after the bound complex is warmed up to 35 °C for several hours.