We are grateful to the EPSRC and the BBSRC for studentships (M.W. and V.G.) and the Royal Society Newton Fellowship Scheme (E.C.). dppz=Dipyridylphenazine.
Temperature-Switched Binding of a RuII(dppz)/DNA Light-Switch Complex†
Article first published online: 18 OCT 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 48, pages 12107–12110, November 26, 2012
How to Cite
Walker, M. G., Gonzalez, V., Chekmeneva, E. and Thomas, J. A. (2012), Temperature-Switched Binding of a RuII(dppz)/DNA Light-Switch Complex . Angew. Chem. Int. Ed., 51: 12107–12110. doi: 10.1002/anie.201206260
- Issue published online: 21 NOV 2012
- Article first published online: 18 OCT 2012
- Manuscript Received: 4 AUG 2012
- Royal Society Newton Fellowship Scheme
- DNA binding;
- light-switch effect;
Cool to switch on: Although a Ru(dppz)-based complex binds to the grooves of duplex DNA at room temperature and above, it intercalates into duplex DNA at 10 °C, thus displaying a light-switch effect (see picture, dppz=dipyridylphenazine). Furthermore, once intercalated at low temperatures, emission does not disappear, even after the bound complex is warmed up to 35 °C for several hours.