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Keywords:

  • C-H activation;
  • domino reaction;
  • heterocycles;
  • palladium;
  • spirooxindoles
Thumbnail image of graphical abstract

Heck shortens the distance: A method for the palladium-catalyzed activation of a C(sp3)[BOND]H bond by a σ-alkyl PdII complex generated in situ from a remote arylhalide function has been developed. This approach allows a novel domino carbopalladation/C(sp3)[BOND]C(sp3) bond-forming process to provide rapid access to biologically relevant spirooxindoles.