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Tandem Heck/Decarboxylation/Heck Strategy: Protecting-Group-Free Synthesis of Symmetric and Unsymmetric Hydroxylated Stilbenoids

Authors

  • Amit Shard,

    1. Natural Plant Products Division, C.S.I.R.-Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur-176061 (H.P.) (India)
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  • Naina Sharma,

    1. Natural Plant Products Division, C.S.I.R.-Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur-176061 (H.P.) (India)
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  • Richa Bharti,

    1. Natural Plant Products Division, C.S.I.R.-Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur-176061 (H.P.) (India)
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  • Sumit Dadhwal,

    1. Natural Plant Products Division, C.S.I.R.-Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur-176061 (H.P.) (India)
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  • Rajesh Kumar,

    1. Natural Plant Products Division, C.S.I.R.-Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur-176061 (H.P.) (India)
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  • Arun K. Sinha

    Corresponding author
    1. Natural Plant Products Division, C.S.I.R.-Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur-176061 (H.P.) (India)
    • Natural Plant Products Division, C.S.I.R.-Institute of Himalayan Bioresource Technology, Council of Scientific and Industrial Research, Palampur-176061 (H.P.) (India)
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  • This work was supported by the Council of Scientific and Industrial Research (project MLP 0008 and MLP 0052/ORIGIN). A.S. and R.K. thank the C.S.I.R. for an SRF award. The authors gratefully acknowledge the Director the IHBT, Palampur, for his kind cooperation and encouragement. I.H.B.T. Communication No. 2384.

Abstract

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Ride the (micro)wave: The title strategy has been developed for the synthesis of various symmetric or unsymmetric hydroxylated stilbenoids utilizing 4-halophenols and acrylic acid as coupling partners (see scheme; DMA=N,N-dimethylacetamide, MW=microwave). Protecting groups are not necessary and a single palladium catalyst is used.

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