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Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro

Authors

  • Florian Rechenmacher,

    1. Institute for Advanced Study at the Department of Chemistry, Technische Universität München (Germany)
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    • These authors contributed equally to this work.

  • Stefanie Neubauer,

    1. Institute for Advanced Study at the Department of Chemistry, Technische Universität München (Germany)
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    • These authors contributed equally to this work.

  • Dr. Julien Polleux,

    1. Max Planck Institut für Biochemie, Department of Molecular Medicine, Martinsried (Germany)
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  • Dr. Carlos Mas-Moruno,

    1. Institute for Advanced Study at the Department of Chemistry, Technische Universität München (Germany)
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  • Dr. Mariarosaria De Simone,

    1. Institute for Advanced Study at the Department of Chemistry, Technische Universität München (Germany)
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  • Dr. Elisabetta Ada Cavalcanti-Adam,

    1. Max Planck-Institute for Intelligent Systems, Department of New Materials and Biosystems, Stuttgart (Germany)
    2. University of Heidelberg, Institute for Physical Chemistry, Department of Biophysical Chemistry, Heidelberg (Germany)
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  • Prof. Joachim P. Spatz,

    1. Max Planck-Institute for Intelligent Systems, Department of New Materials and Biosystems, Stuttgart (Germany)
    2. University of Heidelberg, Institute for Physical Chemistry, Department of Biophysical Chemistry, Heidelberg (Germany)
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  • Prof. Reinhard Fässler,

    1. Max Planck Institut für Biochemie, Department of Molecular Medicine, Martinsried (Germany)
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  • Prof. Dr. Horst Kessler

    Corresponding author
    1. Institute for Advanced Study at the Department of Chemistry, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching (Germany) http://www.org.chemie.tu-muenchen.de
    2. Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589 (Saudi Arabia)
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  • We thank the IGSSE (International Graduate School of Science and Engineering), the Bund der Freunde der TU München e.V., CompInt (Materials Science of Complex Interfaces) of the Elite Network of Bavaria for funding, IAS (Institute for Advanced Study) of Technische Universität München, CIPSM (Center for Integrated Protein Science Munich), and the Max Planck Society for financial support.

Abstract

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Stuck with the right choice: αvβ3- or α5β1-selective integrin ligands were functionalized for surface coating without losing activity and selectivity. The coating of nanostructured gold surfaces with these compounds stimulated subtype-selective cell adhesion of genetically modified αvβ3- or α5β1-expressing fibroblasts in vitro.

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