This work was supported by the Fonds der Chemischen Industrie (Liebig fellowship to T.G.).
Nanoparticles and Peptides: A Fruitful Liaison for Biomimetic Catalysis†
Article first published online: 4 OCT 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 45, pages 11202–11204, November 5, 2012
How to Cite
Stodulski, M. and Gulder, T. (2012), Nanoparticles and Peptides: A Fruitful Liaison for Biomimetic Catalysis . Angew. Chem. Int. Ed., 51: 11202–11204. doi: 10.1002/anie.201206373
- Issue published online: 30 OCT 2012
- Article first published online: 4 OCT 2012
- Manuscript Received: 8 AUG 2012
- Fonds der Chemischen Industrie
Inspired by nature: Self-assembled peptide nanoparticles have been designed that accelerate ester hydrolysis (see picture; Cbz=carbobenzyloxy, NP=p-NO2-C6H4). The concerted interplay of the multivalent surface with the catalytically active peptide and the substrate at the same time combines several aspects decisive for the catalyst's efficiency, a property characteristic of enzymes.