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Nanoparticles and Peptides: A Fruitful Liaison for Biomimetic Catalysis


  • This work was supported by the Fonds der Chemischen Industrie (Liebig fellowship to T.G.).


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Inspired by nature: Self-assembled peptide nanoparticles have been designed that accelerate ester hydrolysis (see picture; Cbz=carbobenzyloxy, NP=p-NO2-C6H4). The concerted interplay of the multivalent surface with the catalytically active peptide and the substrate at the same time combines several aspects decisive for the catalyst's efficiency, a property characteristic of enzymes.