Assembly of Heterogeneous Functional Nanomaterials on DNA Origami Scaffolds

Authors

  • Dr. Risheng Wang,

    Corresponding author
    1. Department of Applied Physics & Applied Mathematics, Columbia University, New York, NY 10027 (USA)
    2. Department of Chemistry, Columbia University, New York, NY 10027 (USA)
    • Department of Applied Physics & Applied Mathematics, Columbia University, New York, NY 10027 (USA)
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  • Prof. Colin Nuckolls,

    1. Department of Chemistry, Columbia University, New York, NY 10027 (USA)
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  • Prof. Shalom J. Wind

    Corresponding author
    1. Department of Applied Physics & Applied Mathematics, Columbia University, New York, NY 10027 (USA)
    • Department of Applied Physics & Applied Mathematics, Columbia University, New York, NY 10027 (USA)
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  • We gratefully acknowledge financial support from the Office of Naval Research under Award N00014-09-1-1117. Additional support from the Nanoscale Science and Engineering Initiative of the National Science Foundation under NSF Award CHE-0641523 and from the New York State Office of Science, Technology, and Academic Research (NYSTAR) is also gratefully acknowledged.

Abstract

original image

One on each side: Gold nanoparticles (AuNPs) and semiconducting quantum dots (QDs) are integrated on a single DNA origami scaffold. Streptavidin-functionalized QDs bind to biotin anchors on one side of the DNA origami, while DNA-coated AuNPs bind through DNA hybridization to single-stranded DNA on the other side of the scaffold. This approach offers a new path toward the organization of complex systems consisting of disparate materials.

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