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Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres

Authors

  • Dr. Amirali Popat,

    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
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  • Dr. Benjamin P. Ross,

    1. School of Pharmacy, The University of Queensland, Brisbane, QLD 4072 (Australia)
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  • Dr. Jian Liu,

    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
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  • Siddharth Jambhrunkar,

    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
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  • Prof. Freddy Kleitz,

    Corresponding author
    1. Department of Chemistry and Centre de recherche sur les matériaux avancés (CERMA), Université Laval, Quebec, G1V0A6, QC (Canada)
    • Department of Chemistry and Centre de recherche sur les matériaux avancés (CERMA), Université Laval, Quebec, G1V0A6, QC (Canada)
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  • Prof. Shi Zhang Qiao

    Corresponding author
    1. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
    2. School of Chemical Engineering, The University of Adelaide, SA 5005 (Australia)
    • Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072 (Australia)
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  • This work was financially supported by the Australian Research Council (ARC) through Linkage Project program (LP0882681) and Discovery Project program (DP1095861, DP1094070, DP0987969). F.K. acknowledges financial support from the Natural Sciences and Engineering Research Council of Canada (NSERC) and the AER program of the Université Laval.

Abstract

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I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.

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