We thank Fundación ICIQ and the Spanish Ministerio de Economía (CTQ2011-25027) for financial support.
Defined Hypervalent Iodine(III) Reagents Incorporating Transferable Nitrogen Groups: Nucleophilic Amination through Electrophilic Activation†
Article first published online: 3 DEC 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 4, pages 1324–1328, January 21, 2013
How to Cite
Souto, J. A., Martínez, C., Velilla, I. and Muñiz, K. (2013), Defined Hypervalent Iodine(III) Reagents Incorporating Transferable Nitrogen Groups: Nucleophilic Amination through Electrophilic Activation . Angew. Chem. Int. Ed., 52: 1324–1328. doi: 10.1002/anie.201206420
- Issue published online: 15 JAN 2013
- Article first published online: 3 DEC 2012
- Manuscript Revised: 1 OCT 2012
- Manuscript Received: 9 AUG 2012
- Fundación ICIQ
- Spanish Ministerio de Economía. Grant Number: CTQ2011-25027
- iodine(III) reagents;
Only I and N: Hypervalent iodine(III) reagents with two reactive IN single bonds have been isolated for the first time. Their solid-state and solution structures provide evidence for enhanced electrophilicity at iodine and nucleophilic character of the imine. As a result, improved reactivity in amination reactions and unprecedented nitrogen-transfer reactions under metal-free conditions are realized.