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Intermolecular [2+2] Reaction of N-Allenylsulfonamides with Vinylarenes: Enantioselective Gold(I)-Catalyzed Synthesis of Cyclobutane Derivatives


  • Generous financial support by the Spanish MINECO and the Principality of Asturias (Grants CTQ2010-20517-C02-01 and FC-11CO11-17) are acknowledged. S.S.-P. and C.H.-D. are grateful to the Spanish Government for FPU and FPI predoctoral fellowships, respectively. We thank Dr. A. Suárez-Sobrino for his kind and helpful assistance for the processing of the X-Ray data.


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Golden touch: N-allenylsulfonamides react with styrene derivatives to furnish chiral cyclobutanes in both high yield and enantioselectivity at −70 °C. Phosphoramidite ligands such as 1, facilitate this asymmetric gold(I)-catalyzed [2+2] cycloaddition. Tf=trifluoromethanesulfonyl.

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