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An RNA–Deaminase Conjugate Selectively Repairs Point Mutations

Authors


  • We thank the DFG (1053/3-1), the Fonds der Chemischen Industrie, and the University of Tübingen for generous financial support and Christoph Kröner and Clemens Richert for MALDI-TOF mass analysis.

Abstract

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Checking for mistakes: By conjugating a catalytic domain with a guide RNA, deamination activity can be harnessed to repair a specific codon on mRNA. This method can be used for the highly selective repair of point mutations in mRNA by site-selective editing.

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