These authors contributed equally to this work.
Photo- and Thermoresponsive Polymersomes for Triggered Release†
Article first published online: 5 NOV 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 50, pages 12499–12503, December 7, 2012
How to Cite
Amstad, E., Kim, S.-H. and Weitz, D. A. (2012), Photo- and Thermoresponsive Polymersomes for Triggered Release . Angew. Chem. Int. Ed., 51: 12499–12503. doi: 10.1002/anie.201206531
The authors thank Maximilian Zieringer for fruitful discussions and help with characterization of the PNIPAM-b-PLGA with gel permeation chromatography. This work was supported by Amore-Pacific, the NSF (grant number DMR-1006546), and the Harvard MRSEC (grant number DMR-0820484). E.A. thanks the Swiss National Foundation for financial support (grant number PBEZP2_137304). Electron microscopy was performed at the center for nanoscale systems (CNS), a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the National Science Foundation under NSF award number ECS-0335765. CNS is part of Harvard University.
- Issue published online: 4 DEC 2012
- Article first published online: 5 NOV 2012
- Manuscript Revised: 10 OCT 2012
- Manuscript Received: 14 AUG 2012
- NSF. Grant Number: DMR-1006546
- Harvard MRSEC. Grant Number: DMR-0820484
- Swiss National Foundation. Grant Number: PBEZP2_137304
- National Nanotechnology Infrastructure Network. Grant Number: ECS-0335765
Microfluidics: Thermo- and photoresponsive polymersomes are assembled using capillary microfluidic devices. Encapsulants can be selectively released from the thermoresponsive polymersomes if they are incubated at and above temperatures of 40 °C, whereas the photoresponsive polymersomes selectively release encapsulants if illuminated with laser light (see picture; NP=nanoparticle).