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Communication

Photo- and Thermoresponsive Polymersomes for Triggered Release†

  1. Dr. Esther Amstad1,‡,
  2. Prof. Dr. Shin-Hyun Kim1,2,‡,
  3. Prof. Dr. David A. Weitz1,*

Article first published online: 5 NOV 2012

DOI: 10.1002/anie.201206531

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 50, pages 12499–12503, December 7, 2012

Additional Information

How to Cite

Amstad, E., Kim, S.-H. and Weitz, D. A. (2012), Photo- and Thermoresponsive Polymersomes for Triggered Release . Angew. Chem. Int. Ed., 51: 12499–12503. doi: 10.1002/anie.201206531

Author Information

  1. 1

    School of Engineering and Applied Sciences, Department of Physics, Harvard University, Cambridge, MA 02138 (USA) http://weitzlab.seas.harvard.edu/

  2. 2

    Department of Chemical and Biomolecular Engineering, KAIST, Daejeon (South Korea)

  1. ‡

    These authors contributed equally to this work.

*School of Engineering and Applied Sciences, Department of Physics, Harvard University, Cambridge, MA 02138 (USA) http://weitzlab.seas.harvard.edu/

  1. †

    The authors thank Maximilian Zieringer for fruitful discussions and help with characterization of the PNIPAM-b-PLGA with gel permeation chromatography. This work was supported by Amore-Pacific, the NSF (grant number DMR-1006546), and the Harvard MRSEC (grant number DMR-0820484). E.A. thanks the Swiss National Foundation for financial support (grant number PBEZP2_137304). Electron microscopy was performed at the center for nanoscale systems (CNS), a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the National Science Foundation under NSF award number ECS-0335765. CNS is part of Harvard University.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 4 DEC 2012
  2. Article first published online: 5 NOV 2012
  3. Manuscript Revised: 10 OCT 2012
  4. Manuscript Received: 14 AUG 2012

Funded by

  • Amore-Pacific
  • NSF. Grant Number: DMR-1006546
  • Harvard MRSEC. Grant Number: DMR-0820484
  • Swiss National Foundation. Grant Number: PBEZP2_137304
  • National Nanotechnology Infrastructure Network. Grant Number: ECS-0335765

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Keywords:

  • membrames;
  • microfluidics;
  • polymers;
  • polymersomes;
  • vesicles
Thumbnail image of graphical abstract

Microfluidics: Thermo- and photoresponsive polymersomes are assembled using capillary microfluidic devices. Encapsulants can be selectively released from the thermoresponsive polymersomes if they are incubated at and above temperatures of 40 °C, whereas the photoresponsive polymersomes selectively release encapsulants if illuminated with laser light (see picture; NP=nanoparticle).

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