The Total Synthesis of Corallopyronin A and Myxopyronin B

Authors

  • Dr. Andreas Rentsch,

    1. Institut für Organische Chemie and Centre of Biomolecular Drug Research (BMWZ), Leibniz University Hannover, Schneiderberg 1B, 30167 Hannover (Germany)
    2. Helmholtz Centre for Infection Research (HZI), Inhoffenstrasse 7, Braunschweig (Germany)
    Search for more papers by this author
  • Prof. Dr. Markus Kalesse

    Corresponding author
    1. Institut für Organische Chemie and Centre of Biomolecular Drug Research (BMWZ), Leibniz University Hannover, Schneiderberg 1B, 30167 Hannover (Germany)
    2. Helmholtz Centre for Infection Research (HZI), Inhoffenstrasse 7, Braunschweig (Germany)
    • Institut für Organische Chemie and Centre of Biomolecular Drug Research (BMWZ), Leibniz University Hannover, Schneiderberg 1B, 30167 Hannover (Germany)
    Search for more papers by this author

  • This work was supported by the Deutsche Forschungsgemeinschaft (DFG Ka 913/16-1). We thank Dr. K. Gerth for a picture of Corallococcus coralloides.

Abstract

original image

Leading the way: The synthesis of natural products with new biological targets is one of the driving forces for the development of new antibiotics. The synthesis of the two secondary metabolites corallopyronin and myxopyronin (see picture) have been achieved, which are prominent leads for the inhibition of bacterial RNA polymerase.

Ancillary