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Keywords:

  • intracellular delivery;
  • polymers;
  • nanoparticles;
  • stem cells;
  • RNA interference
Thumbnail image of graphical abstract

Larger is better: Fas-silencing siRNA can be delivered into the cytoplasm of human mesenchymal stem cells (hMSCs) by a bioreducible polymer (see picture). The enhanced anti-apoptotic activity of the Fas-silenced hMSCs means that they can be readily formulated as enlarged spheroids to significantly enhance angiogenic efficacy as compared to their smaller counterparts.