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A Bioreducible Polymer for Efficient Delivery of Fas-Silencing siRNA into Stem Cell Spheroids and Enhanced Therapeutic Angiogenesis

Authors

  • Dr. Min Suk Shim,

    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
    2. Current address: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University; School of Chemistry & Biochemistry and School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 (USA)
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    • These authors contributed equally to this work.

  • Dr. Suk Ho Bhang,

    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
    2. Current address: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University; School of Chemistry & Biochemistry and School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 (USA)
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    • These authors contributed equally to this work.

  • Dr. Kyunghwan Yoon,

    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
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  • Prof. Kyunghee Choi,

    1. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 (USA)
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  • Prof. Younan Xia

    Corresponding author
    1. Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
    2. Current address: The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University; School of Chemistry & Biochemistry and School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332 (USA)
    • Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 (USA)
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Errata

This article is corrected by:

  1. Errata: Corrigendum: A Bioreducible Polymer for Efficient Delivery of Fas-Silencing siRNA into Stem Cell Spheroids and Enhanced Therapeutic Angiogenesis Volume 52, Issue 8, 2147, Article first published online: 13 February 2013

  • This work was supported in part by an NIH Director’s Pioneer Award (DP1 OD000798 to Y.X.) and NIH grants from the National Heart, Lung and Blood Institute (NHLBI, R01 HL55337 and R01 HL63736 to K.C.). We thank Dennis Oakley of the Bakewell Neuroimaging Core at Washington University School of Medicine for assistance with the confocal microscopy imaging.

Abstract

original image

Larger is better: Fas-silencing siRNA can be delivered into the cytoplasm of human mesenchymal stem cells (hMSCs) by a bioreducible polymer (see picture). The enhanced anti-apoptotic activity of the Fas-silenced hMSCs means that they can be readily formulated as enlarged spheroids to significantly enhance angiogenic efficacy as compared to their smaller counterparts.

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