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Trans-Platinum/Thiazole Complex Interferes with Sp1 Zinc-Finger Protein

Authors

  • Siming Chen,

    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
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  • Dechen Xu,

    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
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  • Huan Jiang,

    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
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  • Zhaoyong Xi,

    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
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  • Prof. Pingping Zhu,

    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
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  • Prof. Yangzhong Liu

    Corresponding author
    1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
    • CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui (China), Fax: (+86) 551-3600874
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  • This work was supported by the National Basic Research Program of China (973 Program, 2012CB932502, 2009CB918804), the National Science Foundation of China (21171156), and the Fundamental Research Funds for the Central Universities.

Abstract

original image

No trafficking: The antitumor-active trans-platinum/thiazole complex trans-PtTz demonstrated high reactivity to the transcription factor Sp1, which is overexpressed in tumor cells. The binding of trans-PtTz disrupts the DNA interaction with Sp1 in vitro and prevents the protein trafficking from the cytoplasm into the nucleus (see picture).

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