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Palladium-Catalyzed Dehydrogenation/Oxidative Cross-Coupling Sequence of β-Heteroatom-Substituted Ketones

Authors

  • Youngtaek Moon,

    1. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701 (Korea)
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  • Daeil Kwon,

    1. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701 (Korea)
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  • Prof. Dr. Sungwoo Hong

    Corresponding author
    1. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701 (Korea)
    • Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701 (Korea)
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  • This research was supported by the National Research Foundation of Korea (NRF) through general research grants (NRF-2010-0022179, 2011-0016436, 2011-0020322).

Abstract

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Concise and selective: The title one-pot sequence allows formation of the enone functionality and subsequent cross-coupling. The process provides access to highly functionalized cyclic enolones and enaminones from readily accessible β-heteroatom-substituted cyclic ketones.

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