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Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide


  • Generous financial support from the MPG and the Fonds der Chemischen Industrie (Kekulé stipend to J.W.) is gratefully acknowledged. We thank the Analytical Departments of our Institute for the excellent cooperation.


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Subtle but distinctive: The stereostructure of the biologically highly promising antimitotic agent leiodermatolide was uncertain. A short, efficient, and flexible total synthesis based on ring-closing alkyne metathesis as the key step has now solved the puzzle. Subtle differences in the 1H NMR spectra of the structure shown and the conceivable isomer proved invaluable for the assignment.