This study is supported by the National Basic Research Program of China (973 program; No.2013CB932800), NSFC (20832004, 20972148), and CAS (KJCX2-EW-J02).
Copper-Promoted Trifluoromethylation of Primary and Secondary Alkylboronic Acids†
Article first published online: 9 NOV 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 50, pages 12551–12554, December 7, 2012
How to Cite
Xu, J., Xiao, B., Xie, C.-Q., Luo, D.-F., Liu, L. and Fu, Y. (2012), Copper-Promoted Trifluoromethylation of Primary and Secondary Alkylboronic Acids . Angew. Chem. Int. Ed., 51: 12551–12554. doi: 10.1002/anie.201206681
- Issue published online: 4 DEC 2012
- Article first published online: 9 NOV 2012
- Manuscript Received: 2 OCT 2012
- National Basic Research Program of China. Grant Number: 2013CB932800
- NSFC. Grant Numbers: 20832004, 20972148
- CAS. Grant Number: KJCX2-EW-J02
- alkyl boronic acids;
New couple: The Cu-promoted trifluoromethylation of primary and secondary alkylboronic acids with TMSCF3 extends the scope of transition-metal-catalyzed trifluoromethylation reactions to sp3-hybridized carbon centers. It also represents one of the first examples for Cu-catalyzed CC cross-coupling reactions of alkylboronic acid derivatives.