A Novel Small Molecule Facilitates the Reprogramming of Human Somatic Cells into a Pluripotent State and Supports the Maintenance of an Undifferentiated State of Human Pluripotent Stem Cells

Authors

  • Dr. Jungwoon Lee,

    1. Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (S. Korea)
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  • Yan Xia,

    1. College of Pharmacy, Dongguk University-Seoul, 26 Pildong-3-ga, Junggu, Seoul 100-715 (S. Korea)
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  • Mi-Young Son,

    1. Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (S. Korea)
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  • Guanghai Jin,

    1. College of Pharmacy, Dongguk University-Seoul, 26 Pildong-3-ga, Junggu, Seoul 100-715 (S. Korea)
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  • Binna Seol,

    1. Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (S. Korea)
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  • Min-Jeong Kim,

    1. Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (S. Korea)
    2. University of Science & Technology, 113 Gwahank-ro, Yuseong-gu, Daejeon 305-333 (S. Korea)
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  • Dr. Myung Jin Son,

    1. Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (S. Korea)
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  • Misol Do,

    1. Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (S. Korea)
    2. University of Science & Technology, 113 Gwahank-ro, Yuseong-gu, Daejeon 305-333 (S. Korea)
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  • Minho Lee,

    1. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (S. Korea)
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  • Prof. Dongsup Kim,

    1. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (S. Korea)
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  • Prof. Kyeong Lee,

    Corresponding author
    1. College of Pharmacy, Dongguk University-Seoul, 26 Pildong-3-ga, Junggu, Seoul 100-715 (S. Korea)
    • College of Pharmacy, Dongguk University-Seoul, 26 Pildong-3-ga, Junggu, Seoul 100-715 (S. Korea)
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    • These authors contributed equally to this work.

  • Dr. Yee Sook Cho

    Corresponding author
    1. Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (S. Korea)
    2. University of Science & Technology, 113 Gwahank-ro, Yuseong-gu, Daejeon 305-333 (S. Korea)
    • Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (S. Korea)
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    • These authors contributed equally to this work.


  • This work was supported by the NRF grant (2010-020272(3) and 2012M3A9C7050224) and the KRIBB/KRCF stem cell research initiative program (NAP).

Abstract

original image

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

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