These authors contributed equally to this work.
Light-Addressable Capsules as Caged Compound Matrix for Controlled Triggering of Cytosolic Reactions†
Article first published online: 14 NOV 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 2, pages 695–699, January 7, 2013
How to Cite
Ochs, M., Carregal-Romero, S., Rejman, J., Braeckmans, K., De Smedt, S. C. and Parak, W. J. (2013), Light-Addressable Capsules as Caged Compound Matrix for Controlled Triggering of Cytosolic Reactions . Angew. Chem. Int. Ed., 52: 695–699. doi: 10.1002/anie.201206696
This work was supported by BMBF/ERANET (project Nanosyn) and the DFG (project PA794/11.1). We acknowledge technical discussions with Drs. Rafael Fernandez Chacón, Loretta del Mercato, Arnold Grünweller, Roland Hartmann, Pilar Riveral Gil and Gleb B. Sukhorukov.
- Issue published online: 28 DEC 2012
- Article first published online: 14 NOV 2012
- Manuscript Revised: 25 OCT 2012
- Manuscript Received: 18 AUG 2012
- DFG. Grant Number: PA794/11.1
- enzyme catalysis;
- gene expression;
- polymeric capsules
Release me: Polyelectrolyte capsules with different cargo in their cavities and plasmonic and magnetic nanoparticles in their walls were synthesized. Enzymatic reactions were triggered inside cells by light-mediated opening of two individual capsules containing either an enzyme or its substrate, by using photothermal heating. Furthermore, this technique allows controlled release of mRNA from capsules, thereby resulting in synthesis of green fluorescent protein (GFP).