These authors contributed equally to this work.
Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles†
Article first published online: 18 OCT 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 47, pages 11836–11840, November 19, 2012
How to Cite
Koo, H., Lee, S., Na, J. H., Kim, S. H., Hahn, S. K., Choi, K., Kwon, I. C., Jeong, S. Y. and Kim, K. (2012), Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles . Angew. Chem. Int. Ed., 51: 11836–11840. doi: 10.1002/anie.201206703
This study was funded by the Global Research Laboratory (GRL) Project, the Fusion Technology Project (2009-0081876), and the Intramural Research Program (Theragnosis) of KIST.
- Issue published online: 14 NOV 2012
- Article first published online: 18 OCT 2012
- Manuscript Received: 18 AUG 2012
- Global Research Laboratory (GRL) Project
- Fusion Technology Project. Grant Number: 2009-0081876
- Intramural Research Program (Theragnosis) of KIST
- click chemistry;
- drug delivery;
- metabolic glycoengineering;
- tumor targeting
Right on target: An in vivo tumor-targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an in vivo bioorthogonal copper-free click reaction.