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Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles

Authors

  • Dr. Heebeom Koo,

    1. Center for Theragnosis, Biomedical Research Institute, Ko-rea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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    • These authors contributed equally to this work.

  • Sangmin Lee,

    1. Department of Life and Nanopharmaceutical Science, Kyung Hee University (Korea)
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    • These authors contributed equally to this work.

  • Jin Hee Na,

    1. Department of Life and Nanopharmaceutical Science, Kyung Hee University (Korea)
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  • Dr. Sun Hwa Kim,

    1. Center for Theragnosis, Biomedical Research Institute, Ko-rea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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  • Dr. Sei Kwang Hahn,

    1. Department of Materials Science and Engineering, Pohang, University of Science and Technology (Korea)
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  • Dr. Kuiwon Choi,

    1. Center for Theragnosis, Biomedical Research Institute, Ko-rea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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  • Dr. Ick Chan Kwon,

    1. Center for Theragnosis, Biomedical Research Institute, Ko-rea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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  • Dr. Seo Young Jeong,

    1. Department of Life and Nanopharmaceutical Science, Kyung Hee University (Korea)
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  • Dr. Kwangmeyung Kim

    Corresponding author
    1. Center for Theragnosis, Biomedical Research Institute, Ko-rea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
    • Center for Theragnosis, Biomedical Research Institute, Ko-rea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea)
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  • This study was funded by the Global Research Laboratory (GRL) Project, the Fusion Technology Project (2009-0081876), and the Intramural Research Program (Theragnosis) of KIST.

Abstract

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Right on target: An in vivo tumor-targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an in vivo bioorthogonal copper-free click reaction.

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