These authors contributed equally to this work.
Silicon-Nanowire-Based Nanocarriers with Ultrahigh Drug-Loading Capacity for In Vitro and In Vivo Cancer Therapy†
Article first published online: 11 DEC 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 5, pages 1457–1461, January 28, 2013
How to Cite
Peng, F., Su, Y., Wei, X., Lu, Y., Zhou, Y., Zhong, Y., Lee, S.-T. and He, Y. (2013), Silicon-Nanowire-Based Nanocarriers with Ultrahigh Drug-Loading Capacity for In Vitro and In Vivo Cancer Therapy . Angew. Chem. Int. Ed., 52: 1457–1461. doi: 10.1002/anie.201206737
The authors appreciate financial support from the National Basic Research Program of China (973 program, grant numbers 2013CB934400 and 2012CB932400), NSFC (grant numbers 30900338 and 51072126), the Research Grants Council of HKSAR (grant numbers CityU5/CRF/08 and CityU 101608), and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).
- Issue published online: 23 JAN 2013
- Article first published online: 11 DEC 2012
- Manuscript Revised: 26 NOV 2012
- Manuscript Received: 20 AUG 2012
- National Basic Research Program of China. Grant Numbers: 2013CB934400, 2012CB932400
- NSFC. Grant Numbers: 30900338, 51072126
- Research Grants Council of HKSAR. Grant Numbers: CityU5/CRF/08, CityU 101608
- Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- cancer therapy;
- drug delivery;
A pratical agent for cancer therapy: Silicon nanowires (SiNWs) were employed in the design of high-performance drug nanocarriers. The SiNWs were used as nanovectors for the delivery of an anticancer drug (DOX). SiNWs feature an ultrahigh drug-loading capacity. In vitro and in vivo experiments show that SiNW-based nanocarriers are highly efficacious for cancer therapy (see picture).