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Silicon-Nanowire-Based Nanocarriers with Ultrahigh Drug-Loading Capacity for In Vitro and In Vivo Cancer Therapy

Authors

  • Fei Peng,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
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    • These authors contributed equally to this work.

  • Dr. Yuanyuan Su,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
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    • These authors contributed equally to this work.

  • Xinpan Wei,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
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  • Yimei Lu,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
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  • Yanfeng Zhou,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
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  • Yiling Zhong,

    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
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  • Prof. Shuit-Tong Lee,

    Corresponding author
    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
    • Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
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  • Prof. Yao He

    Corresponding author
    1. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
    • Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123 (China)
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  • The authors appreciate financial support from the National Basic Research Program of China (973 program, grant numbers 2013CB934400 and 2012CB932400), NSFC (grant numbers 30900338 and 51072126), the Research Grants Council of HKSAR (grant numbers CityU5/CRF/08 and CityU 101608), and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

Abstract

original image

A pratical agent for cancer therapy: Silicon nanowires (SiNWs) were employed in the design of high-performance drug nanocarriers. The SiNWs were used as nanovectors for the delivery of an anticancer drug (DOX). SiNWs feature an ultrahigh drug-loading capacity. In vitro and in vivo experiments show that SiNW-based nanocarriers are highly efficacious for cancer therapy (see picture).

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