Copper-Catalyzed Amination of Ketene Silyl Acetals with Hydroxylamines: Electrophilic Amination Approach to α-Amino Acids


  • This work was partly supported by Grants-in-Aid from the MEXT and JSPS (Japan).


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Role reversal: The title reaction has been developed to deliver α-amino acids under very mild reaction conditions (see scheme; dpppen=1,5-bis(diphenylphosphino)pentane). The catalysis provides a new C[BOND]N bond-forming approach for the synthesis of α-amino acids by using an umpolung, electrophilic amination strategy.