Rational Synthesis for All All-Homocalixarenes


  • This work was supported by the NSF grant CHE-0750319.


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Have it all: The synthesis of homocalixarenes of all sizes has been demonstrated using the triple annulation of bis(carbene) complexes with diynes (see scheme). This strategy in principle should allow access to all homocalixarenes. The generality of the synthetic approach is also demonstrated by the preparation of a pyrrole-containing calixarene.