Construction of an All-Carbon Quaternary Stereocenter by the Peptide-Catalyzed Asymmetric Michael Addition of Nitromethane to β-Disubstituted α,β-Unsaturated Aldehydes

Authors


  • This work was supported by JSPS KAKENHI (23750171 to K.A. and 23550116 to K.K.), and by MEXT KAKENHI (24105506 to K.K.). The authors thank Mr. Atsushi Okumura for experimental assistance.

Abstract

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Pepping up Michael: An asymmetric Michael addition of nitromethane to β-disubstituted α,β-unsaturated aldehydes was realized by a resin-supported peptide catalyst. Whereas the use of a low-molecular-weight catalyst resulted in poor yields, the peptide effectively promoted the reaction in aqueous media with high enantioselectivity.

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