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Keywords:

  • biomimetic model;
  • cleavage reactions;
  • dioxygenases;
  • enzyme models;
  • iron
Thumbnail image of graphical abstract

Biomimetic aromatic ring cleavage: An iron(II)-2-aminophenolate complex (see picture, right) with a tetradentate ligand reacts with dioxygen to cleave the aromatic C[BOND]C bond of 2-amino-4-tert-butylphenolate to form 4-tert-butyl-2-picolinate. This complex represents a functional model of 2-aminophenol-1,6-dioxygenase (APD) and 3-hydroxyanthranilate-3,4-dioxygenase (HAD).