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Intrinsically Copper-64-Labeled Organic Nanoparticles as Radiotracers

Authors

  • Tracy W. Liu,

    1. Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
    2. Department of Medical Biophysics, University of Toronto (Canada)
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    • These authors contributed equally to this work.

  • Thomas D. MacDonald,

    1. Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
    2. Department of Pharmaceutical Sciences, University of Toronto (Canada)
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    • These authors contributed equally to this work.

  • Dr. Jiyun Shi,

    1. Department of Medical Biophysics, University of Toronto (Canada)
    2. Medical Isotopes Research Center, Peking University, Beijing (China)
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  • Prof.Dr. Brian C. Wilson,

    1. Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
    2. Department of Medical Biophysics, University of Toronto (Canada)
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  • Prof.Dr. Gang Zheng

    Corresponding author
    1. Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
    2. Department of Medical Biophysics, University of Toronto (Canada)
    3. Department of Pharmaceutical Sciences, University of Toronto (Canada)
    • Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN (Canada)
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  • We would like to thank Dr. Warren Foltz for assistance with MR imaging, Tab Siddiqi and Dr. David Green for assistance with the radioUPLC, Dr. Helen Lee, Dr. Jinzi Zhang, and Dr. Wing-Ki Liu for assistance with the pharmacokinetics study, Cheng S. Jin for assistance with the orthotopic prostate cancer model, Dr. David Jaffray and the staff of the STTARR facility for assisting with obtaining 64Cu, and Todd Cunningham for illustrating Figure 2 A. Funding was provided by CIHR, OICR, SERC, CFI, the Princess Margaret Cancer Foundation, MaRS Innovation, Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research, and the US Army BCRP Predoctoral Award W81XWH-10-1-0115.

Abstract

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PET friendly: Labels for PET imaging are incorporated into completely organic porphysomes by using a fast (30 min), one-pot, high-yielding (>95 %) procedure to produce highly stable (>48 h) radiolabeled nanoparticles that show the highest specific activity ever reported for a 64Cu-labeled nanoparticle. These 64Cu-porphysomes can be accurately and noninvasively tracked in vivo.

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