Periodic Mesoporous Organosilica-Based Nanocomposite Hydrogels as Three-Dimensional Scaffolds

Authors

  • Dr. Nermin Seda Kehr,

    Corresponding author
    1. Physikalisches Institut and Center for Nanotechnology, Westfälische Wilhelms-Universität Münster, Heisenbergstrasse 11, 48149 Münster (Germany)
    • Physikalisches Institut and Center for Nanotechnology, Westfälische Wilhelms-Universität Münster, Heisenbergstrasse 11, 48149 Münster (Germany)
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  • Eko Adi Prasetyanto,

    1. Physikalisches Institut and Center for Nanotechnology, Westfälische Wilhelms-Universität Münster, Heisenbergstrasse 11, 48149 Münster (Germany)
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  • Kathrin Benson,

    1. Institut für Biochemie, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Strasse 2, 48149 Münster (Germany)
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  • Bahar Ergün,

    1. Department of Chemistry, Biochemistry Division, Hacettepe University, 06800 Ankara (Turkey)
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  • Anzhela Galstyan,

    1. Physikalisches Institut and Center for Nanotechnology, Westfälische Wilhelms-Universität Münster, Heisenbergstrasse 11, 48149 Münster (Germany)
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  • Prof. Hans-Joachim Galla

    1. Institut für Biochemie, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Strasse 2, 48149 Münster (Germany)
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  • This work has been supported by DFG (SFB 858).

Abstract

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Dye-loaded periodic mesoporous organosilica particles functionalized with bioactive molecules were used for the generation of a nanocomposite alginate hydrogel. The affinity of cells was up to four times higher with the embedded particles than with simple alginate hydrogel, caused by both the nanometer-scale particle itself and its bioactive functionalization.

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