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Keywords:

  • enantioselectivity;
  • hydroamination;
  • metathesis;
  • stereoselectivity;
  • synthetic methods
Thumbnail image of graphical abstract

In control: A new synthetic strategy towards cyclic amines was developed and exploits a stereodefined cyclic N,O-acetal as the key stereocontrol and diversity-generating element. The cyclic N,O-acetal was prepared from the sequential asymmetric hydroamination of an alkoxyallene with the chiral ligand L*, and ring-closing metathesis. The stereochemical integrity of the labile N,O-acetal was conserved in all catalytic transformations.